Effi ciency of allogenic platelet-rich plasmsa, combined with collagen, in rat's humerus injury healing
Abstract
In experiment we studied influence of collagen, filled with platelet-rich plasma (PRP), on rats' bone regeneration in distal humerus. Used dose of PRP contained 130–135 pg/ml platelet-derived growth factor (PDGF). According to this level of PDGF, PRP-collagen treatment rapidly enhanced trabecular bones' growth, stimu-lated angiogenesis and reduced intensity of inflammation. Allogenic PRP, addressed to all experimental animals, allowed to make humerus healing 2 times shorter.
About the Authors
A. Yu. Vaza
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, Moscow
Russian Federation
Russian Federation
M. S. Makarov
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, Moscow
Russian Federation
Russian Federation
V. V. Slastinin
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, Moscow
Russian Federation
Russian Federation
N. V. Borovkova
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, Moscow
Russian Federation
Russian Federation
I. Yu. Klyukvin
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, Moscow
Russian Federation
Russian Federation
D. Yu. Pokhitonov
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, Moscow
Russian Federation
Russian Federation
I. N. Ponomarev
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Vaza A.Yu., Makarov M.S., Slastinin V.V., Borovkova N.V., Klyukvin I.Yu., Pokhitonov D.Yu., Ponomarev I.N. Effi ciency of allogenic platelet-rich plasmsa, combined with collagen, in rat's humerus injury healing. Transplantologiya. The Russian Journal of Transplantation. 2016;(2):36-44.
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