Immune dysfunction in patients with end-stage chronic renal failure
Abstract
This literature review presents an immune system disorder in end-stage renal disease (ESRD), emphasizing the specific role of uremia and related changes. Finally, on the basis of new relationships between the changes in the immune system of ESRD patients, it emphasizes the potential role of the immune dysfunction as the main cause of the high
mortality in this patient population and the need for further research in this area.
mortality in this patient population and the need for further research in this area.
About the Authors
U. A. Dostiev
Tajik State Medical University named after Abu Ali Ibn Sino
Tajikistan
Tajikistan
A. R. Dostiev
Tajik State Medical University named after Abu Ali Ibn Sino
Tajikistan
Tajikistan
A. M. Karimov
Tajik State Medical University named after Abu Ali Ibn Sino
Tajikistan
Tajikistan
References
1. Immunologic function and survival in hemodialysis patients / P.L. Kimmel, T.M. Phillips, S.J. Simmens [et al.] // Kidney Int. – 1998. – Vol. 54, N. 1. – P. 236–244.
2. IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia – the good, the bad, and the ugly / P. Stenvinkel, M. Ketteler, R. Johnson [et al.] // Kidney Int. – 2005. – Vol. 67, N. 4. – P. 1216–1233.
3. Enhanced scavenger receptor expression in monocyte-macrophages in dialysis patients / M. Ando, I. Lundkvist, J. Bergström, B. Lindholm // Kidney Int. – 1996. – Vol. 49, N. 3. – P. 773–780.
4. Impairment of innate cellular response to in vitro stimuli in patients on continuous ambulatory peritoneal dialysis / M. Ando. A.Shibuya, M. Yasuda [et al. ] // Nephrol. Dial. Transplant. – 2005. – Vol. 20, N. 11. – P. 2497–2503.
5. Uremia impairs monocyte and monocytederived dendritic cell function in hemodialysis patients / W.H. Lim, S. Kireta, E. Leedham [et al.] // Kidney Int. – 2007. – Vol. 72, N. 9. – P. 1138– 1148.
6. Functional impairment of monocytederived dendritic cells in patients with severe chronic kidney disease / M.A. Verkade, C.J. van Druningen, L.M. Vaessen [et al.] // Nephrol. Dial. Transplant. – 2007. – Vol. 22, N. 1. – P. 128–138.
7. The influence of uraemia and haemodialysis on neutrophil phagocytosis and antimicrobial killing / K. Anding, P. Gross, J.M. Rost [et al.] // Nephrol. Dial. Transplant. – 2003. – Vol. 18, N. 10. – P. 2067–2073.
8. Glorieux, G. Uraemic retention and apoptosis: what is the balance for the inflammatory status in uraemia? /G. Glorieux, R. Vanholder, N. Lameire // Eur. J. Clin. Invest. – 2003. – Vol. 33, N. 8. – P. 631–634.
9. Immunoglobulin light chains modulate polymorphonuclear leucocyte apoptosis / G. Cohen, M. Rudnicki, R. Deicher, W.H. Hörl // Eur. J. Clin. Invest. – 2003. – Vol. 33, N. 8. – P. 669–676.
10. Glucose-Modified Proteins Modulate Essential Functions and Apoptosis of Polymorphonuclear Leukocytes / G. Cohen, M. Rudnicki, F. Walter [et al. ] // J. Am. Soc Nephrol. – 2001. – Vol. 12, N. 6.- P. 1264–1271.
11. Mortality, malnutrition, and atherosclerosis in ESRD: what is the role of interleukin-6? / P. Stenvinkel, P. Barany, O. Heimbürger [et al.] // Kidney Int. Suppl. – 2002. – N. 80. – P. 103–108.
12. Associations between circulating inflammatory markers and residual renal function in CRF patients / R. Pecoits-Filho, O. Heimbürger, P. Bárány [et al.] // Am. J. Kidney Dis. – 2003. – Vol. 41, N. 6. – P. 1212–1218.
13. Opatrny, K. Clinical importance of biocompatibility and its effect on haemodialysis treatment / K. Opatrny //Nephrol. Dial. Transplant. – 2003. – 18, Suppl. 5. – P.41–44.
14. Biocompatibility of cellulosic and synthetic membranes assessed by leukocyte activation / M.R. Hernández, A.M. Galán, A. Cases [et al.] // Am. J. Nephrol. 2004. – Vol. 24, N. 2. – P. 235–241.
15. Selective blockade of the antigenreceptor-mediated pathway of T-cell activation in patients with impaired primary immune responses / S.C. Meuer, M. Hauer, P. Kurz [et al.] // J. Clin. Invest. – 1987. – Vol. 80, N. 3. – P. 743–749.
16. Signalling via the TCR/CD3 antigen receptor complex in uremia is limited by the receptors number / J. Stachowski, M. Pollok, H. Burrichter [et al.] // Nephron. – 1993. – Vol. 64, N. 3. – P. 369–375.
17. T-cell activation follows Th1 ra ther than Th2 pattern in haemodialysis patients / U. Sester, M. Sester, M. Hauk [et al.] // Nephrol. Dial. Transplant. – 2000. – Vol. 15, N. 8. – P. 1217–1223.
18. Disturbances of acquired immunity in hemodialysis patients / T. Eleftheriadis, G. Antoniadi, V. Liakopoulos [et al.] // Semin Dial. 2007. – Vol. 20, N. 5. – P. 440–451.
19. Uremic serum enhances scavenger receptor expression and activity in the human monocytic cell line U937 / M. Ando, M. Gåfvels, J. Bergström [et al.] // Kidney Int. – 1997. – Vol. 51, N. 3. – P. 785–792.
20. B lymphopenia in uraemia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2 / G. Fernández- Fresnedo, M.A. Ramos, M.C. González-Pardo [et al.] // Nephrol. Dial. Transplant. – 2000. – Vol. 15, N. 4. – P. 502–510.
21. A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease / D. Fouque, K. Kalantar-Zadeh, J. Kopple [et al.] // Kidney Int. 2008. – Vol. 73, N. 4. – P. 391–398.
22. Factors predicting malnutrition in hemodialysis patients: a cross-sectional study / A.R. Qureshi, A. Alvestrand, A. Danielsson [et al.] // Kidney Int. – 1998. – Vol. 53, N. 3. – P. 773–782.
23. Nutritional status and lymphocyte function in maintenance hemodialysis patients / M. Wolfson, C.J. Strong, D.Minturn [et al.] // Am. J. Clin. Nutr. – 1984. – Vol. 39, N. 4. – P. 547–555.
24. White blood cells as a novel morta lity predictor in haemodialysis patients / D.N. Reddan, P.S. Klassen, L.A. Szczech [et al.] // Nephrol. Dial. Transplant.- 2003. – Vol. 18, N. 6. – P. 1167–1173.
25. Schröder, N.W.J. Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease /N.W.J. Schröder, R.R. Schumann // Lancet Infect. Dis. – 2005. – Vol. 5, N. 3. – P. 156–164.
26. Toll-like receptor 4 polymorphisms and atherogenesis / S. Kiechl, E. Lorenz, M. Reindl [et al.] // N. Engl. J. Med. – 2002. – Vol. 347, N. 3. – P. 185–192.
27. Zuany-Amorim, C. Toll-like receptors as potential therapeutic targets for multiple diseases / C. Zuany-Amorim, J. Hastewell, C. Walker // Nat. Rev. Drug Discov. – 2002. – Vol. 1, N. 10. – P. 797–807.
28. Pasare, Ch. Toll-like receptors: linking innate and adaptive immunity / Ch. Pasare, R. Medzhitov // Microbes. Infect. – 2004. – Vol. 6, N. 15. – P. 1382– 1387.
29. Significant elevations in serum mannose-binding lectin levels in patients with chronic renal failure / A. Satomura, M. Endo, H. Ohi [et al.] // Nephron. – 2002. – Vol. 92, N. 3. – P. 702–704.
30. Low pretransplantation mannosebinding lectin levels predict superior patient and graft survival after simultaneous pancreas-kidney transplantation / S.P. Berger, A. Roos, M.J. Mallat [et al.] // J. Am. Soc. Nephrol. – 2007. – Vol. 18, N. 8. – P. 2416–2422.
31.
Review
For citations:
Dostiev U.A., Dostiev A.R., Karimov A.M. Immune dysfunction in patients with end-stage chronic renal failure. Transplantologiya. The Russian Journal of Transplantation. 2016;(4):58-62.
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