The lack of donor organs is the main factor limiting organ transplantation. Currently, the majority of transplants are taken from brain-dead donors. In most cases the brain death is associateed with a severe physiologic instability that may deteriorate the donor organ function prior to the excision or lead to the loss of the donor. An active or even aggressive management of a donor allows the control and correction of pathophysiological processes in donor organs, thus increasing the number and improving the functional condition of donor organs.

An aggressive management strategy for a potential donor with brain death requires to change both the approach to intensive care, and the philosophic aspect in the evaluation of this work. Despite the development and implementation of various protocols for brain-dead donors, an optimum combination of objectives, monitoring, specific therapy has not been worked out yet.

Objective: To determine the efficacy of epidural anesthesia as part of combination inhalation anesthesia in patients undergoing kidney and pancreas transplantation

Material: The study enrolled 21 patients after combined kidney and pancreas transplantation in in the Sklifosovsky Research Institute for Emergency Medicine.

Results: Use of combined inhalation and epidural anesthesia allows for early mobilization of patients after kidney and pancreas transplantation.