The functional geometry of the left ventricle (LV) of heart was investigated in patients after orthotopic heart transplantation without any signs of rejection. Typical features of LV functional geometry in heart transplant recipients with uncomplicated postoperative period were indentified as compared to patients without heart disease. The authors have put forward the hypothesis about a diagnostic value of LV functional geometry parameters for a non-invasive diagnosis of graft dysfunction that would facilitate an optimum correction of treatment tactics.

Early liver allograft dysfunction (EAD) is associated with a high incidence of graft loss and patient mortality in the first 6 weeks after orthotopic liver transplantation (OLT).

The aim of this retrospective single-center study is to identify the risk factors of EAD and to compare the short- and long-term results in EAD and non-EAD groups.

Materials and methods. The results of 213 consecutive deceased donor liver transplantations performed between December 2004 and February 2015 were included in the analysis. Indications for OLT were non-viral liver cirrhosis in 52% of cases, viral hepatitis C or B in 34 %, hepatocellular carcinoma in 8 %; retransplantations were performed in 6% of cases due to previous liver graft dysfunction. EAD was defined by Olthoff criteria (Olthoff et al., 2010).

Results. Overall incidence of EAD was 41.3%, including 5.6% of primary non-function grafts (PNF), i.e. irreversible EAD. No significant differences between EAD and non-EAD groups were seen either among donors in their age, gender, cause of death, bilirubin, plasma sodium level, aminotransferases aktivity, or among the recipients in their age, gender, body mass index, MELD. Retransplantation, donor time on mechanical ventilation in the intensive care unit for more than 2 days, highrisk donor category, transplant surgery duration more than 9.5 hours, and cold ischemia time (CIT) > 8 hours were independent significant risk factors of EAD in a multivariate model. A 42-day mortality rates were 18.2% in EAD group (mostly due to PNF without urgent retransplantanion in 9.1%), and 0% in non-EAD group. Long-term results in EAD group were also significantly poorer: 1-, 5-, and 10-year graft survival rates were 74%, 68%, and 64%, respectively, versus 96%, 90%, and 83% in non-EAD group, Log-rank p = 0.0001.

Conclusion. EAD significantly (≈ 20%) decreases the short-term graft and patient survival rates. Meanwhile, a reversible EAD has no impact on long-term results. Despite the increased risk of EAD, the liver grafts from high-risk donors are suitable for transplantation. The most important and modifiable risk factor is CIT (optimal timeframe 6 - 8 h), especially when HTK solution is used. The risk of EAD / PNF dramatically increases in case of combined donor and 
recipient risk factors.

This article describes the risk and incidence of fungal infections in the early period after liver transplantation, their diagnosis, treatment and prevention. After liver transplant patients have a higher risk of developing invasive fungal infection. The presence of high - risk factors is an absolute indication for prophylactic antifungal medicine.

In experiment we studied influence of collagen, filled with platelet-rich plasma (PRP), on rats' bone regeneration in distal humerus. Used dose of PRP contained 130–135 pg/ml platelet-derived growth factor (PDGF). According to this level of PDGF, PRP-collagen treatment rapidly enhanced trabecular bones' growth, stimu-lated angiogenesis and reduced intensity of inflammation. Allogenic PRP, addressed to all experimental animals, allowed to make humerus healing 2 times shorter.

The article presents an actual information on the detection rate of blood-borne viral infections (BBVI) among blood donors, potential organ and tissue donors in Russia and other countries. The causes of differences in BBVI prevalence between blood donors and potential organ and tissue donors have been analyzed. The BBVI prevalence among potential organ donors was proved to be much higher than among blood donors due to their medical-and-social characteristics.