The article discusses the possible risks of infection by bacterial, fungal and viral infections the recipient of donor organs. Identified infectious diseases in which the reserve of donor organs is contraindicated for the recipient and the diseases for which it is possible to use donor organs.

Authors reviewed published data concerning antiviral treatment of liver transplant recipients with 1st generation HCV protease inhibitors (telaprevir and boceprevir). Efficacy and adverse events have been analyzed with peculiar attention to drug-drug interactions between calcineurin inhibitors and HCV protease inhibitors. The article is illustrated with clinical cases.

Literature data analysis in pancreas transplantation (Tx) is represented in the article. Its history is described. Advantages and disadvantages of different Tx types and long term results are represented in detail. The problem of pancreatic islets Tx is briefly delineated.

After the diagnosis of brain death has been made, the donor management is a continuation of the previous intensive care. The paper reviews the brain death donor management standards established on the basis of a physiologically justified active approach.

The maim elements of the donor management protocol include the invasive monitoring of the central and peripheral hemodynamic parameters, the correction of hemodynamic impairments, and hypothermia, the use of hormonal therapy, an adequate mechanical lung ventilation.

An active or even aggressive brain death donor management allows the control and correction of pathophysiological processes, thereby increasing the number and improving the functional state of donor organs.